DNA Sequencing and PCR Markets - Biotechnology, Healthcare and Life Sciences Publishing

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Report Description

DNA Sequencing and PCR Markets
Publication Date: 01-JUL-08
Pages: 185
Study: TMRPCR
Format/Price: PDF document / $3,400.00

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The focus of this TriMark Publications report is to describe the specific segment of the life sciences market called DNA sequencing. This analysis includes all of the generally-accepted DNA-oriented analytical activities that are currently used today, such as enabling technologies like polymerase chain reaction (PCR). It examines these measurement technology platforms and their reagents and supplies as utilized in biotechnology research, pharmacology and healthcare. Generally, diagnostic tests which are marketed primarily as over-the-counter products directly to patients are not included in this study, although there is inevitably some overlap. This examination will: 1) identify viable technology drivers through a comprehensive look at various platform technologies for molecular sequencing, including immunoassays electrophoretic methods, probe-based nucleic acid assays, microarrays and non-PCR sequencing; 2) obtain a complete understanding of the chief molecular sequencing tests for predictive, screening, prognostic, monitoring, pharmacogenomic and theranostic applications; 3) discover feasible market opportunities via an identification of high-growth applications in different therapeutic areas, with a focus on the biggest and expanding markets-communicable diseases, cardiology and oncology; and 4) focus on global industry development through an in-depth analysis of the major world markets for molecular sequencing, including forecasts for growth.

Table of Contents:

1. Overview 6
1.1 Statement of Report 6
1.2 About This Report 6
1.3 Scope of the Report 6
1.4 Methodology 7
1.5 Executive Summary 8
2. Introduction to DNA Sequencing and Amplification and PCR Technology 10
2.1 Science Overview: Introduction to DNA 10
2.1.1 DNA Sequencing and PCR Applications Space 14
2.1.2 Proteomics 15
2.1.3 Products for the Genomics Market 15
2.2 The Impact of the Human Genome Project on Molecular Biology 15
2.3 Impact of DNA Sequencing Techniques on Biotechnology, Pharmaceutical and Healthcare Industries 15
2.4 Molecular Diagnostics in the Post-genomic Era-The Role of SNPs 16
2.5 Advances in Molecular Diagnostic Technologies 17
2.6 The Use of PCR Technology 18
2.7 Genetic Variability and Disease 19
3. Market Analysis of PCR and DNA Sequencing Product Market 21
3.1 Overview of the Sequencing and Amplification Market 21
3.1.1 Highlights of DNA Sequencing Market 23
3.1.2 Genomic Analysis Market Development 23
3.1.3 Leading U.S. and Canadian Companies Offering Sequencing Technology Platforms 24
3.1.4 Competition 27
3.1.5 Markets for DNA Sequencing 28
3.1.6 Market Opportunity 29
3.1.7 Market Dynamics 30
3.1.8 Overview of Current DNA Sequencing Technology Platforms and Players 31
3.1.9 Limitations of Current Sequencing Technologies 52
3.1.10 Overview of the Life Science Marketplace 55
3.1.11 Research Laboratories 58
3.1.11.1 Market Share 59
3.2 Paradigm Shift in Drug Discovery and Development 59
3.2.1 Systems Biology and the Need for More Effective Tools 60
3.2.2 Molecular Medicine and the New Therapeutics 60
3.2.3 Pharmacogenomics Using Genotyping and Phenotyping Clinical Biomarkers 60
3.2.4 The Market 61
3.3 Detection of Amplified DNA 61
3.3.1 Nucleic Acid Amplification Methods 62
3.3.2 Amplification of Refractory Mutation System (ARMS) 64
3.4 DNA Reagent Applications Market Share and Key Players 64
3.4.1 Product Description 64
3.4.1.1 Pricing 64
3.5 PCR/DNA Testing Market Analysis 66
3.5.1 Nucleic Acid-Amplification and Detection Systems: How Big a Market? 66
3.5.2 Market Size 2004-2010 and Growth Projections in DNA Amplification Instrumentation 66
3.5.2.1 U.S. Market 66
3.5.2.2 European Market 66
3.5.3 Market Share of Key Players in DNA Amplification 67
3.6 The Drivers of the Biotech Industry 67
3.6.1 Isolation of DNA for PCR Profiling 68
3.6.2 Analysis by PCR-Based DNA Typing 68
3.6.3 Rapid Isolation of DNA for RFLP and PCR 68
3.6.4 DNA for PCR-STR Typing 69
3.7 Biotechnology Instrumentation Outlook 69
3.7.1 Products for the Genomics Market 69
3.7.2 Genetic Analysis Products 70
4. Use of PCR and DNA Amplification Products 72
4.1 PCR Components 72
4.1.1 Primers for PCR 72
4.1.2 Equipment for PCR 72
4.2 Sources of DNA for PCR 75
4.3 PCR Primer Sequence 75
4.4 Thermostable DNA Polymerases 76
4.5 PCR Protocols 77
4.6 Microfluidic Automated DNA Analysis Using PCR 78
5. Technical Trends in PCR 79
5.1 Practical Applications of PCR 79
5.1.1 Overview 79
5.2 Quality Control Issues in PCR 79
5.3 Determining Length of cDNA Product 79
5.3.1 Direct Signal Amplification Using the Invader Assay 79
5.3.2 Biosensor Technologies 81
5.3.2.1 DNA Hybridization Biosensor Chips 81
5.3.2.2 PNA-Based Biosensors 82
5.4 Novel Nucleic Acid Amplification Techniques 82
5.5 Microplate Readers 83
5.6 Genotyping Methods 83
5.6.1 Use of DNA Sequencers 83
5.6.1.1 Capillary-Based Sequencers 84
5.6.1.2 Pyrosequencing 85
5.6.2 Use of Microarrays 86
5.7 RiboMaker Detection System 86
5.8 RNA Isolation Kits 87
5.9 Nucleic Acid Sample Prep Platforms 88
5.10 DNA Microarrays 89
5.10.1 The Technique 89
5.10.2 The Market 89
5.10.3 Gene Expression Monitoring Arrays 90
5.11 Emerging Markets of DNA Arrays 90
5.12 Alternatives to PCR Amplification 90
5.12.1 Locked Nucleic Acids (LNAs) 90
5.12.2 Multiplexed Nuclease-Protection Assay and ArrayPlate 91
6. Corporate Directory 93
6.1 Abbott Laboratories 93
6.2 Affymetrix 94
6.3 Agilent Technologies 101
6.4 AgriGen Biotech Pty 102
6.5 GE Healthcare 102
6.6 Applera Applied Biosystems 103
6.7 Avesthagen Gengraine Technologies, Pvt. 106
6.8 Bayer Corporation 106
6.9 BD Biosciences 107
6.10 Beckman Coulter 108
6.11 BGI Life Tech 110
6.12 bioMérieux 111
6.13 Bioneer 112
6.14 Bio-Rad Laboratories 112
6.15 BioTrove 113
6.16 Caliper LifeSciences 114
6.17 Cepheid 117
6.18 Cogenics (A subsidiary of Clinical Data) 118
6.19 CombiMatrix Corporation 119
6.20 Commonwealth Biotechnologies 121
6.21 Complete Genomics 122
6.22 CuraGen Corporation 122
6.23 Cytocell 124
6.24 Dako A/S 124
6.25 DiaDexus 124
6.26 DNA LandMarks 125
6.27 DNAVision 126
6.28 Enzo Biochem 126
6.29 Epicentre 126
6.30 Eppendorf AG 127
6.31 Eurofins Medigenomix 127
6.32 Exiqon 127
6.33 Febit Biomed 128
6.34 Geneart AG 128
6.35 GeneticTechnologies Limited 128
6.36 GeneWorks 129
6.37 Genisphere 129
6.38 Genizon BioSciences 129
6.39 Genovoxx 130
6.40 Gen-Probe 130
6.41 Genset 134
6.42 Genta 134
6.43 Genzyme 135
6.44 GVK BIO 137
6.45 Hamilton Thorne Biosciences 137
6.46 Helicos BioSciences Corporation 137
6.47 High Throughput Genomics 138
6.48 Hokkaido System Science 138
6.49 Hy Laboratories 138
6.50 Illumina 138
6.51 Incyte Corporation 143
6.52 Integrated DNA Technologies 144
6.53 Invitrogen 144
6.54 Inqaba Biotechnical Industries 146
6.55 Johnson & Johnson 146
6.56 Kreatech Holding BV 147
6.57 LI-COR 148
6.58 Sygnis Pharma AG 148
6.59 Lucigen 149
6.60 Luminex Corporation 149
6.61 Meridian Biosciences 151
6.62 Microchip Biotechnologies 153
6.63 Microsynth AG 153
6.64 MilleGen SA 154
6.65 Millennium Pharmaceuticals 154
6.66 MWG Biotech AG 154
6.67 Myriad Genetics 154
6.68 Nanogen 156
6.69 Nanosys 158
6.70 Nymox 159
6.71 Ocimum Biosolutions 160
6.72 Orchid Cellmark 161
6.73 Ostex 161
6.74 Pacific Biosciences 161
6.75 PamGene 161
6.76 Perlegen Sciences 162
6.77 PPD 162
6.78 PPGx 162
6.79 PrimmBiotech 162
6.80 Promega 162
6.81 Biotage 163
6.82 QIAGEN 163
6.83 Quidel 165
6.84 Research Biolabs Pte 167
6.85 Roche Diagnostics 167
6.86 Shanghai Sangon Biological Engineering Technology & Services Co. 168
6.87 Saturn Biotech 168
6.88 Sequenom 169
6.89 Sequetech 170
6.90 Shimadzu Biotech 170
6.91 Siemens AG 170
6.92 Tepnel Life Sciences 171
6.93 Third Wave Technologies 171
6.94 Visible Genetics 173
6.95 VisiGen Biotechnologies 173
6.96 Vysis 173
6.97 Wellcome Trust Sanger Institute 174
6.98 ZS Genetics 174
7. Market Trends and Forecasts 175
7.1 Market Dynamics 175
7.2 Future Considerations for Molecular Diagnostics 175
7.3 How Genomics is Transforming Pharmaceutical R&D 175
7.4 Cancer Markers 176
7.5 NAT and Personalized Medicine 176
7.6 Three Growth Areas of Molecular Diagnostics 176
7.7 RNA Detection 177
7.8 Ramification Amplification Method 177
7.9 Invader Assays/Third Wave Technologies 178
7.10 Molecular Beacons 179
8. Major Product Innovations/Launches in DNA Sequencing Industry 181
8.1 Major Product Innovations/Launches in DNA Sequencing Industry 181
8.2 Major Activities in DNA Sequencing Industry 183
LIST OF FIGURES
Figure 2.1: Segment of Double-Stranded DNA Showing the Base-Pair Relationship 11
Figure 3.1: Global Market for DNA Sequencing 22
Figure 4.1: Cepheid's I-CORE Module 78
LIST OF TABLES
Table 3.1: Global Market for DNA Sequencing 21
Table 3.2: DNA Sequencing Market Players 24
Table 3.3: Major DNA Product Companies in Europe 25
Table 3.4: Major DNA Product Companies in Asia and Australia 25
Table 3.5: Major DNA Product Companies in Japan 25
Table 3.6: Major DNA Product Companies in Rest of the World 25
Table 3.7: Market Revenue and Market Share of DNA Sequencing Market Players 31
Table 3.8: Thermal Cyclers Marketed by Applied Biosystems 46
Table 3.9: Applied Biosystems' Real-Time PCR Systems 46
Table 3.10: Applied Biosystems Genetic Analysis Instruments 48
Table 3.11: Gene Expression Assays Offered by Applied Biosystems 49
Table 3.12: SNP Genotyping Assays Offered by Applied Biosystems 49
Table 3.13: Comparison of Established Genomic Analysis Technologies 54
Table 3.14: Life Science Techniques Frequently Used 55
Table 3.15: The Most Commonly Used Reagents Used by Life Science Researchers 55
Table 3.16: The Most Commonly Used Instruments and Apparatus in Life Science Research 56
Table 3.17: The Most Widely Reported Categories of Software in Life Science Research 56
Table 3.18: Reagents and Equipment Sales for Use in DNA Sequencing Worldwide 56
Table 3.19: Global Market for Tools and Consumables Used in Drug Discovery and Development, Clinical Diagnostics and Biomedical Research 58
Table 3.20: Key Bioassay Technologies in the Life Sciences Industry 59
Table 3.21: Nucleic Acid Amplification Methods 62
Table 3.22: Properties of Various Acid Amplification Techniques 63
Table 3.23: Amplification Reagent Product Description 64
Table 3.24: Standard Prep Pricing 65
Table 3.25: Small Target Prep Pricing 65
Table 3.26: Hybridization Pricing 65
Table 3.27: Analysis Pricing 66
Table 3.28: U.S. Market Size 2004-2010 in DNA Amplification Instrumentation 66
Table 3.29: Market Share of Key Players in DNA Amplification Thermostable Enzymes 67
Table 3.30: Leading Manufacturers of Thermal Cyclers and Market Share 67
Table 4.1: ThermoFisherMolecular Biology Thermal Cyclers 73
Table 4.2: PCR Systems and Thermocyclers 74
Table 5.1: RiboMaker™ Assays to be Introduced for Cancer and Pathogen Detection 87
Table 8.1: The Key Bioassay Technologies in the Life Sciences Industry 181

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