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This TriMark Publications report deals primarily with the analysis of market segments of microscopes used in clinical and research laboratories. Emphasis is on the U.S. markets; however, the worldwide markets are analyzed and discussed as well. Specifically, this report examines those companies and products which are actively developing and marketing microscopy devices and supplies in market segments which have the potential for growth rates above 5% per year over the next five years. It continues to examine those microscopy devices operated as light, confocal, electron and scanning probe microscopes. Also analyzed are applications for certain microscope technology platforms such as semi-conductor processing systems and automated imaging systems. Concentration is centered on an overview of individual microscopy markets, which are believed to possess the elements that will lead to sustained growth rates for the foreseeable future. This report assesses the current status of each market, makes projections for market size, discusses the market strategies of leading companies in each market segment, and evaluates the forces that underlie the high growth of each segment. Additionally, there's an overview of the instruments and supplies marketed by major companies in each market segment. Analysis of the market size, growth rates, and market components for instruments used for microscopy are also discussed.

1. 1 Overview 6
2. 1.1 Statement of Report 6
3. 1.2 Scope of This Report 6
4. 1.3 Objectives 7
5. 1.4 Methodology 8
6. 1.5 Aims of This Report 9
7. 1.6 Executive Summary 9
8. 1.7 Trends and Conclusions 10
10. 2 Introduction to Microscopy Markets 11
11. 2.1 Overview of Microscopy Technologies 11
12. 2.1.1 Introduction 11
13. 2.1.2 Basic Optical Microscopy (OM) 11
14. 2.1.3 Electron Microscopy (EM) and Other Charged-Particle Technologies 12
15. 2.1.4 Advanced Optical Microscopy 13
16. 2.1.5 Scanning Probe Microscopy (SPM) 13
17. 2.1.6 Fourier Transform Infrared Microscopy (FT-IR) 14
18. 2.1.7 Ultraviolet Microscopy (UVM) 14
19. 2.1.8 Scanning Acoustic Microscopy (SAM) 14
20. 2.1.9 X-Ray Microscopy / Microtomography (MCT, XMT, Micro-CT) 14
21. 2.2 Market Perspective 14
22. 2.3 Market Analysis 15
23. 2.3.1 Market Size 16
24. 2.3.2 Market Share 17
25. 2.3.3 Key Players 17
26. 2.3.4 Competition 18
27. 2.3.5 Barriers to Growth 18
28. 2.3.6 Market Drivers 18
29. 2.4 Purchasers' Perspectives 19
31. 3 In-Depth Discussion of Optical (Light) Microscopy (OM) 21
32. 3.1 Lens Systems 22
33. 3.2 Resolution 23
34. 3.3 Illumination Systems 23
35. 3.4 Innovations 24
36. 3.4.1 Stereo Microscopes 24
37. 3.5 Major Applications of Optical Microscopy 25
38. 3.5.1 Semiconductor Manufacturing 25
39. 3.5.2 Automated Medical Imaging 26
40. 3.5.3 Market Drivers for Automated Systems for Semiconductor and Medical Applications 28
41. 3.5.4 Real-Time Imaging 28
43. 4 In-Depth Discussion of Light-Based Fluorescence, Multi-Photon and Confocal Microscopy 29
44. 4.1 Fluorescence Microscopy 29
45. 4.2 Total Internal Reflection Fluorescence Microscopy (TIRFM) 30
46. 4.3 Multi-Photon Microscopy 30
47. 4.3.1 Basic Principles 30
48. 4.3.2 Lasers 30
49. 4.3.3 Fluorophores for Multi-Photon Work 31
50. 4.3.4 Uncaging 31
51. 4.3.5 Autofluorescence 31
52. 4.4 Laser Scanning Confocal Microscopy (Confocal, LSCM) 31
53. 4.4.1 Basic Principles 32
54. 4.4.2 Confocal System Types 33
55. 4.4.3 Photobleaching 33
56. 4.5 High-Throughput Fluorescence and Confocal Imaging Systems 33
57. 4.6 Major Players and Products in Optical, Fluorescence, Multi-Photon and Confocal Microscopy 34
58. 4.6.1 BD (Becton, Dickinson and Company) 34
59. 4.6.2 KLA-Tencor Corporation 34
60. 4.6.3 Korima, Inc. 35
61. 4.6.4 Leica Microsystems, Inc. 35
62. 4.6.5 Nikon Instruments, Inc. 38
63. 4.6.6 Nanomics Imaging, Inc. 39
64. 4.6.7 Olympus Imaging America, Inc. 39
65. 4.6.8 Veeco Instruments, Inc. 40
66. 4.6.9 Carl Zeiss Microimaging, Inc. 41
67. 4.6.10 Modular Confocal Scanners 42
69. 5 In-Depth Discussion of Scanning Probe Microscopy (SPM), Including Near-Field (NSOM) and Atomic Force Microscopy (AFM) 44
70. 5.1 Introduction 44
71. 5.2 Near-Field Scanning Optical Microscopy (NSOM) 44
72. 5.2.1 Resonance Frequency 45
73. 5.2.2 Aperture 45
74. 5.2.3 Reflection Mode 45
75. 5.3 Near-Field Scanning Thermal Microscopy (NThM) 45
76. 5.4 Atomic Force Microscopy (AFM) 45
77. 5.4.1 Semiconductor Applications 46
78. 5.4.2 Magnetic Material Applications 46
79. 5.4.3 Electrochemical Applications 46
80. 5.4.4 Life Sciences Applications 46
81. 5.5 Major Players and Products in Scanning Probe Microscopy (Including Near-Field and Atomic Force) 47
82. 5.5.1 Agilent Technologies 47
83. 5.5.2 Asylum Research 47
84. 5.5.3 JEOL USA, Inc. 47
85. 5.5.4 KLA-Tencor Corporation 48
86. 5.5.5 Nanonics Imaging, Ltd. 48
87. 5.5.6 Omicron NanoTechnology GmbH 49
88. 5.5.7 Veeco Instruments, Inc. 49
89. 5.5.8 WITec Instruments Corp. 51
91. 6 In-Depth Discussion of Infrared and Ultraviolet Microscopy 52
92. 6.1 Fourier-Transfer Infrared Microscopy (FT-IR) 52
93. 6.2 Ultraviolet Microscopy (UVM) 52
94. 6.3 Major Players and Products for Infrared and Ultraviolet Microscopy 53
95. 6.3.1 Bruker Optics, Inc. 53
96. 6.3.2 Craic Technologies 53
97. 6.3.3 KLA-Tencor Corporation 53
98. 6.3.4 Korima, Inc. 54
99. 6.3.5 Thermo Scientific 54
101. 7 In-Depth Discussion of Scanning Acoustic Microscopy, X-Ray Microtomography and Raman Spectroscopic Microscopy 55
102. 7.1 Scanning Acoustic Microscopy (SAM) 55
103. 7.2 X-Ray Microtomography (CTM, Micro-CT) 56
104. 7.3 Raman Spectroscopic Microscopy 56
106. 8 Major Players and Products in Acoustic Microscopy, X-Ray Microtomography and Raman Microscopy 58
107. 8.1 Major Players in Acoustic Microscopy 58
108. 8.1.1 Sonix, Inc. 58
109. 8.1.2 Sonoscan, Inc. 58
110. 8.2 Major Players in X-Ray Microtomography 59
111. 8.2.1 Cameca Instruments, Inc. 59
112. 8.2.2 SkyScan 59
113. 8.3 Major Players in Raman Microscopy 59
114. 8.3.1 Horiba Jobin Yvon, Inc. 59
115. 8.3.2 Renishaw, Inc. 60
116. 8.3.3 Thermo Scientific 60
118. 9 In-Depth Discussion of Electron Microscopy (EM) and Related Charged-Particle Systems 61
119. 9.1 Transmission Electron Microscope (TEM) 61
120. 9.1.1 Electron Sources 62
121. 9.2 Scanning Electron Microscope (SEM) 63
122. 9.2.1 Rastering 63
123. 9.2.2 Exploring the Sample 64
124. 9.2.3 Types of Image 64
125. 9.2.4 Environmental SEM (ESEM) and Variable-Pressure SEM (VPSEM) 65
126. 9.2.5 Low-Voltage SEM 66
127. 9.2.6 Tabletop Models 66
128. 9.2.7 Applications 66
129. 9.3 Scanning/Transmission Electron Microscope (STEM) 66
130. 9.4 Electron Probe Microanalyzer (EPMA, Microprobe) 67
131. 9.5 Auger Electron Microscopy/Spectroscopy (AES, AEM, Auger) 68
132. 9.6 Electron Beam (E-Beam) Lithography 68
133. 9.7 Focused Ion Beam (FIB) and Dual-Beam Microscopes 69
134. 9.8 Secondary Ion Mass Spectrometry (SIMS) 69
135. 9.9 X-Ray Photoelectron Spectroscopy (XPS)/ Electron Spectroscopy for Chemical Analysis (ESCA) 70
136. 9.10 Scanning Helium Ion Beam Microscopy (SHIM) 70
138. 10 Ancillary Analytical Attachments 71
139. 10.1 Common/Historical Attachments 71
140. 10.1.1 Energy-Dispersive (EDS) and Wavelength-Dispersive (WDS) X-ray Microanalyzers 71
141. 10.1.2 Electron Backscatter Diffraction (EBSD) 71
142. 10.1.3 Cathodoluminescence (CL) 71
143. 10.1.4 X-Ray Microtomography 71
144. 10.1.5 Raman Spectroscopy 72
146. 11 Major Players and Products in Electron Beam and Other Charged-Particle Beam Microscopies 73
147. 11.1 Cameca Instruments, Inc. 73
148. 11.2 FEI Company 74
149. 11.3 Hitachi High Technologies America, Inc. 79
150. 11.4 JEOL USA, Inc. 81
151. 11.5 KLA-Tencor Corporation 86
152. 11.6 Omicron NanoTechnology GmbH 86
153. 11.7 Vistec Lithography, Inc. 87
154. 11.8 Carl Zeiss SMT Corporation 88
156. 12 Company Profiles 90
157. 12.1 Applied Materials, Inc. 90
158. 12.2 Applied Precision, Inc. 91
159. 12.3 Becton, Dickinson and Company 91
160. 12.4 Bio-Rad Laboratories, Incorporated 92
161. 12.5 Bruker Optics 93
162. 12.6 Buehler 93
163. 12.7 Cameca 94
164. 12.8 Carl Zeiss, Inc. 94
165. 12.9 Danish Micro Engineering A/S 96
166. 12.10 FEI Company 97
167. 12.11 Gatan 98
168. 12.12 Genetix 99
169. 12.13 Hitachi, Ltd. 99
170. 12.14 Inami Corp. 101
171. 12.15 IRIS International 101
172. 12.16 JEOL 103
173. 12.17 KLA-Tencor Corporation 104
174. 12.18 Leica Microsystems (part of Danaher Corporation) 107
175. 12.19 Medical Integrated Services (MIS) 108
176. 12.20 Nanonics Imaging, Ltd. 108
177. 12.21 Nikon, Inc. 109
178. 12.22 NT-MDT 110
179. 12.23 Obducat-CamScan 110
180. 12.24 Olympus Corporation 111
181. 12.25 Omicron Nanotechnology 113
182. 12.26 Pacific Nanotechnology 113
183. 12.27 Park Systems (formerly PSIA) 113
184. 12.28 PerkinElmer 113
185. 12.29 Quesant Instruments 119
186. 12.30 Questar Corporation 119
187. 12.31 Schott North America 120
188. 12.32 Shimadzu Corporation 121
189. 12.33 SII NanoTechnology 121
190. 12.34 Thermo Fisher Scientific, Inc. 121
191. 12.35 TM Microscopes (ThermoMicroscopes) 125
192. 12.36 TriPath Imaging, Inc. 126
193. 12.37 Veeco Instruments 126
194. 12.38 WITec (Wissenschaftliche Instrumente und Technologie) GmbH 128
196. 13 Company Directory 129
199. INDEX OF FIGURES
201. Figure 2.1: Global Market for Microscopes, Accessories and Supplies, 2003-2012 16
202. Figure 3.1: Basic Components of the Optical Microscope 21
203. Figure 3.2: Stereo Microscope 24
206. INDEX OF TABLES
208. Table 2.1: Global Market for Microscopes and Accessories, 2007-2013 16
209. Table 2.2: Global Market for Optical Microscopes and Accessories 17
210. Table 2.3: Global Market for Charged Particle Microscopes and Accessories 17
211. Table 2.4: Global Market for Scanning Probe Microscopes and Accessories 17
212. Table 3.1: Basic Components of the Optical Microscope 21
213. Table 5.1: Types of Scanning Probe Microscopes 44