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A microarray is an arrangement of miniaturized test sites or "spots" on a surface. Each spot is usually no more than 250 micrometers in diameter and contains biological molecules--usually DNA or protein--which act as probes for a test sample applied to the array. The surface may be a glass slide, a plastic plate with wells or a polymer bead. The microarray format allows many tests or experiments to be performed simultaneously, in parallel, leading to the generation of huge amounts of biological information for the application of only a tiny amount of sample. Microarrays are often also known as "biochips". The purpose of this TriMark Publications report is to describe the specific segment of the microarray market aimed at analysis of proteins and DNA. Protein microarray applications include: 1) expression profiling; 2) serum-based diagnostics; 3) protein-protein binding assays; 4 drug-target binding; and 5) receptor epitope binding. It examines the market for DNA and protein array testing equipment and supplies using screening reagents and instruments for analysis of individual components in blood, serum or plasma. It defines the dollar volume of sales, both worldwide and in the U.S., and analyzes the factors that influence the size and the growth of the market segments. Also examined are the subsections of each market segment, including the research labs, hospital labs, and commercial laboratories. Additionally, the numbers of institutions using this type of testing and the factors that influence purchases are discussed. The report surveys almost all of the companies known to be marketing, manufacturing or developing instruments and reagents for the protein array market in the U.S. Each company is discussed in depth with a section on its history, product line, business and marketing analysis, and a subjective commentary of the company's market position. The five main objectives of this analysis are:

· Identifying viable technology drivers through a comprehensive look at platform technologies for DNA and protein arrays, including, probe-based nucleic acid assays, microarrays and sequencing.

· Obtaining a complete understanding of the chief DNA and protein array tests from their basic principles to their applications.

· Discovering feasible market opportunities by identifying high-growth applications in different analytical diagnostic areas, focusing on the biggest and expanding markets.

· Focusing on global industry development through an in-depth analysis of the major world markets for DNA and protein array technology, including growth forecasts.

· Present market figures regarding the current value of the microarray market, projections and growth rates. The source of this information is the most current data derived from the global diagnostic industry.

By purchasing this report, you will have:

· An understanding of the most exciting microarray market segments, current and future.

· The latest information on leading products and research and development (R&D) initiatives.

· Familiarity with recent developments and their effects on selected markets.

· Knowledge of the microarray market as an area of growth, research and investment.

Key questions answered in this report:

· How can microarray tools and technologies facilitate drug discovery, design and development?

· What are the main types of array technologies that are currently available?

· Who are the current key players in this marketplace?

· Which microarray market areas have the greatest potential for growth?

· What is the current state of the microarray market?

· Which biotechnology and pharmaceutical companies are investing in microarray solutions?

· What are the main microarray business strategies adopted by leading companies?

· What are the benefits of microarray technology platforms?

This report contains:

· Detailed analysis of recent trends in the microarray marketplace.

· In-depth profiles of 16 leading companies with microarray tools and technologies.

· A five-year forecast for the microarray market in the biotechnology and pharmaceutical industries.

· Views and principles on the microarray industry from leading industry experts.

· Analysis of potential microarray applications in the life science sector.

· Market predictions and trends analysis concerning U.S. expenditure on array solutions.

· Projections for future applications of microarrays in drug discovery, from the industry's R&D perspective.

· Analysis of commercial microarray business strategies.

· The latest news and developments in the microarray marketplace.

· A comprehensive overview and insight into microarray business strategies.

1. 1. Overview 4
2. 1.1 Statement of Report 4
3. 1.2 About This Report 4
4. 1.3 Scope of the Report 5
5. 1.4 Objectives 6
6. 1.5 Methodology 6
7. 1.6 Executive Summary 7
9. 2. Overview of Microarrays 9
10. 2.1 History of Microarrays 10
11. 2.2 Genomics and Proteomics 11
12. 2.2.1 Genetic Variability and Disease 12
13. 2.3 General Theory of Microarrays 12
14. 2.4 DNA Microarrays 14
15. 2.5 Protein Microarrays 16
16. 2.6 Tissue Microarrays 17
18. 3. DNA Microarrays 19
19. 3.1 Advantages and Drivers 19
20. 3.2 Limitations and Barriers to Commercialization 20
21. 3.3 DNA Microarray Technology Platforms 21
22. 3.3.1 Reasons Why Researchers Utilize DNA Microarrays 25
23. 3.3.2 Factors for Difficulties Applying DNA Microarrays Technology 25
24. 3.4 Key Attributes of DNA Microarray Software 26
25. 3.5 Applications 26
26. 3.6 Future Directions for DNA Microarray Technology 31
27. 3.6.1 High-Throughput Array Technology 32
28. 3.6.2 Emerging Microarray Trends 34
29. 3.6.3 Emerging Microarray Applications 34
30. 3.6.4 Key Points for Developing Microarray Based Applications 35
31. 3.7 Competitive Landscape for DNA Microarrays 35
33. 4. Protein Microarrays 36
34. 4.1 Critical Factors for Microarray Content 36
35. 4.2 Key Findings on Use of Microarrays 36
36. 4.3 Advantages and Drivers 37
37. 4.4 Limitations and Barriers to Commercialization 39
38. 4.5 Key Experimental Parameters of Protein Microarray Technology for Current and Future Users 41
39. 4.6 Reasons Why Researchers Utilize Protein Microarrays 42
40. 4.7 Factors for Adoption of Protein Microarrays Technology 42
41. 4.8 Top Suppliers of Protein Microarray Slides and Products 43
42. 4.9 Factors that Influence Sale Decisions 43
43. 4.10 Future Innovations in Protein Microarray Technology 43
45. 5. Current DNA Microarrays 44
46. 5.1 Key Players 44
47. 5.2.1 Microarray-Based Commercial Genotyping Activity 46
48. 5.2.2 Location Analysis 46
49. 5.3 Future Innovations in DNA Microarray Technology 47
51. 6. Current Protein Microarrays 48
52. 6.1 Protein Profiling Microarrays-Antibody Arrays 48
53. 6.2 Protein Profiling Microarrays-Reverse Phase Microarrays 50
54. 6.3 Multiplex Sandwich Microarrays-Planar 51
55. 6.4 Multiplex Sandwich Immunoassays-Bead Based 54
56. 6.5 Microarrays for Protein Function Studies 56
57. 6.6 High Growth Applications 58
58. 6.6.1 Cytokine Arrays 58
59. 6.6.2 Whole Proteome Arrays 58
60. 6.6.3 Microarray-Based Commercial Genotyping Activity 59
61. 6.6.3.1 Microarray-Based Genotyping Applications 59
62. 6.6.3.2 Microbial Applications 60
63. 6.6.3.3 The Market for Microbial Genotyping Products 61
64. 6.6.3.4 Comparative Genomic Hybridization (CGH) 61
65. 6.6.4 ChIP-on-Chip Analysis 62
67. 7. Technology 64
68. 7.1 Production of Microarrays 64
69. 7.2 2-D Versus 3-D Technology 66
70. 7.3 Substrates and Surface Chemistries 67
71. 7.4 Detection Methods 69
72. 7.5 Instruments 69
73. 7.6 Data Management and Informatics in Gene Expression 69
75. 8. Applications 70
76. 8.1 DNA Microarrays in Gene Expression 70
77. 8.2 DNA Microarrays in SNP Analysis 73
78. 8.3 DNA Microarrays in Cancer 74
79. 8.4 Protein Expression 74
80. 8.4.1 Cytokine Applications 75
81. 8.4.2 Protein Function 75
82. 8.4.3 Protein-Protein Interactions 76
83. 8.5 Target /Biomarker Discovery 76
84. 8.6 Drug Discovery and Development (Gene and Protein Microarrays) 77
85. 8.7 Clinical Diagnostics (Gene and Protein Microarrays) 77
86. 8.8 RNA Microarrays 78
87. 8.9 Oligo Microarrays 79
88. 8.10 Yeast Microarrays 79
89. 8.11 Antibody Arrays 79
90. 8.12 Arrays for Toxicogenomics 80
92. 9. The Commercial Opportunity for Microarrays 81
93. 9.1 Market Drivers for Microarrays 81
94. 9.2 Market Restraints for Microarrays 81
95. 9.3 Key Players 82
96. 9.4 Market Size, Strategic Trends and Competitive Landscape for Protein Arrays 84
97. 9.5 Marketing and Distribution 86
98. 9.6 Protein Arrays Market Analysis 87
99. 9.7 Genes Associated with Major Diseases 88
100. 9.8 Software and Data Analysis 88
101. 9.8.1 Supplier of DNA Microarray Analysis Software 89
102. 9.8.2 Satisfaction with Software Features 89
103. 9.8.3 Satisfaction with Software 89
104. 9.8.4 Supplier Factors in Software Purchase Decision 89
105. 9.8.5 Suppliers' Role in Improving Data Sharing for DNA Microarrays 89
107. 10. Company Profiles 90
108. 10.1 Manufacturers 127
111. LIST OF FIGURES
113. Figure 6.1: Cytokines and Growth Factors: Sources of Microarrays for Cytokine Research 58
114. Figure 8.1: Microbial Genotyping: Applications for DNA Microarrays 73
115. Figure 8.2: Source of Variation in Microarray Data 78
116. Figure 8.3: Toxicogenomics: DNA Microarrays 80
119. LIST OF TABLES
121. Table 3.1: Microarray Product Revenue: Arrays, Reagents and Instruments, 2005 and 2010 19
122. Table 3.2: Microarray Market Drivers 20
123. Table 3.3: Microarray Market Barriers 20
124. Table 3.4: Unit Pricing of DNA Microarrays, 2000-2010 21
125. Table 3.5: Steps in the Design and Implementation of a DNA Microarray Experiment 23
126. Table 3.6: Microarray Applications 26
127. Table 3.7: List of DNA Array Manufacturers 28
128. Table 4.1: Critical Factors for Microarray Content 36
129. Table 4.2: Top Three Suppliers of Treated Protein Microarray Surfaces for Self-Printing 43
130. Table 4.3: Top Suppliers of Commercially Available Protein Microarrays 43
131. Table 4.4: Top Suppliers of Protein Microarray Readers 43
132. Table 5.1: Affymetrix Sales of Probe Arrays, 2000-2007 44
133. Table 5.2: Affymetrix Total Product Sales, 1999-2007 45
134. Table 5.3: Affymetrix Instrument Sales, 2000-2007 45
135. Table 6.1: Microarray Genetic Testing 59
136. Table 6.2: ChIP-on-Chip Microarray Market Size Projections, 2005-2011 62
137. Table 8.1: Applications of Biochips by Class 70
138. Table 8.2: Diagnostics Microarray Market Size Projections, 2005-2011 71
139. Table 8.3: HTS Microarray Market Size Projections, 2005-2011 71
140. Table 8.4: Pharmacogenomics Microarray Market Size Projections, 2005-2011 71
141. Table 8.5: Toxicology Screening Microarray Market Size Projections, 2005-2011 71
142. Table 8.6: Expression Profiling Microarray Market Size Projections, 2005-2011 72
143. Table 9.1: Market Share of Microarray Products, 2006 82
144. Table 9.2: Affymetrix Product Sales 83
145. Table 9.3: Leading Microarray Companies 83
146. Table 9.4: Worldwide Microarray Market Size, 2004-2012 84
147. Table 9.5: Microarray Market Share by Technology Type 85
148. Table 9.6: DNA Microarray U.S. Market Size, 2005-2011 85
149. Table 9.7: DNA Microarray Worldwide Market Size, 2002-2011 85
150. Table 9.8: Biochip Market by Usage, 2003 and 2007 86