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A microarray is an arrangement of miniaturized test sites or "spots" on a surface. Each spot is usually no more than 250 micrometers in diameter and contains biological molecules--usually DNA or protein--which act as probes for a test sample applied to the array. The surface may be a glass slide, a plastic plate with wells or a polymer bead. The microarray format allows many tests or experiments to be performed simultaneously, in parallel, leading to the generation of huge amounts of biological information for the application of only a tiny amount of sample. Microarrays are often also known as "biochips". The purpose of this TriMark Publications report is to describe the specific segment of the microarray market aimed at analysis of proteins and DNA. Protein microarray applications include: 1) expression profiling; 2) serum-based diagnostics; 3) protein-protein binding assays; 4 drug-target binding; and 5) receptor epitope binding. It examines the market for DNA and protein array testing equipment and supplies using screening reagents and instruments for analysis of individual components in blood, serum or plasma. It defines the dollar volume of sales, both worldwide and in the U.S., and analyzes the factors that influence the size and the growth of the market segments. Also examined are the subsections of each market segment, including the research labs, hospital labs, and commercial laboratories. Additionally, the numbers of institutions using this type of testing and the factors that influence purchases are discussed. The report surveys almost all of the companies known to be marketing, manufacturing or developing instruments and reagents for the protein array market in the U.S. Each company is discussed in depth with a section on its history, product line, business and marketing analysis, and a subjective commentary of the company's market position. The five main objectives of this analysis are:

· Identifying viable technology drivers through a comprehensive look at platform technologies for DNA and protein arrays, including, probe-based nucleic acid assays, microarrays and sequencing.

· Obtaining a complete understanding of the chief DNA and protein array tests from their basic principles to their applications.

· Discovering feasible market opportunities by identifying high-growth applications in different analytical diagnostic areas, focusing on the biggest and expanding markets.

· Focusing on global industry development through an in-depth analysis of the major world markets for DNA and protein array technology, including growth forecasts.

· Present market figures regarding the current value of the microarray market, projections and growth rates. The source of this information is the most current data derived from the global diagnostic industry.

By purchasing this report, you will have:

· An understanding of the most exciting microarray market segments, current and future.

· The latest information on leading products and research and development (R&D) initiatives.

· Familiarity with recent developments and their effects on selected markets.

· Knowledge of the microarray market as an area of growth, research and investment.

Key questions answered in this report:

· How can microarray tools and technologies facilitate drug discovery, design and development?

· What are the main types of array technologies that are currently available?

· Who are the current key players in this marketplace?

· Which microarray market areas have the greatest potential for growth?

· What is the current state of the microarray market?

· Which biotechnology and pharmaceutical companies are investing in microarray solutions?

· What are the main microarray business strategies adopted by leading companies?

· What are the benefits of microarray technology platforms?

This report contains:

· Detailed analysis of recent trends in the microarray marketplace.

· In-depth profiles of 16 leading companies with microarray tools and technologies.

· A five-year forecast for the microarray market in the biotechnology and pharmaceutical industries.

· Views and principles on the microarray industry from leading industry experts.

· Analysis of potential microarray applications in the life science sector.

· Market predictions and trends analysis concerning U.S. expenditure on array solutions.

· Projections for future applications of microarrays in drug discovery, from the industry's R&D perspective.

· Analysis of commercial microarray business strategies.

· The latest news and developments in the microarray marketplace.

· A comprehensive overview and insight into microarray business strategies.

1. 1. Overview 4
2. 1.1 Statement of Report 4
3. 1.2 About This Report 4
4. 1.3 Scope of the Report 5
5. 1.4 Objectives 6
6. 1.5 Methodology 6
7. 1.6 Executive Summary 7
9. 2. Overview of Microarrays 9
10. 2.1 History of Microarrays 9
11. 2.2 Genomics and Proteomics 10
12. 2.2.1 Genetic Variability and Disease 11
13. 2.3 General Theory of Microarrays 11
14. 2.4 DNA Microarrays 12
15. 2.5 Protein Microarrays 14
16. 2.6 Tissue Microarrays 15
18. 3. DNA Microarrays 17
19. 3.1 Advantages and Drivers 17
20. 3.2 Limitations and Barriers to Commercialization 18
21. 3.3 DNA Microarray Technology Platforms 19
22. 3.3.1 Reasons Why Researchers Utilize DNA Microarrays 23
23. 3.3.2 Factors for Difficulties Applying DNA Microarrays Technology 23
24. 3.4 Key Attributes of DNA Microarray Software 24
25. 3.5 Applications 24
26. 3.6 Future Directions for DNA Microarray Technology 29
27. 3.6.1 High-Throughput Array Technology 29
28. 3.6.2 Emerging Microarray Trends 31
29. 3.6.3 Emerging Microarray Applications 31
30. 3.6.4 Key Points for Developing Microarray Based Applications 32
31. 4. Protein Microarrays 33
32. 4.1 Critical Factors for Microarray Content 33
33. 4.2 Key Findings on Use of Microarrays 33
34. 4.3 Advantages and Drivers 34
35. 4.4 Limitations and Barriers to Commercialization 36
36. 4.5 Key Experimental Parameters of Protein Microarray Technology for Current and Future Users 38
37. 4.6 Reasons Why Researchers Utilize Protein Microarrays 39
38. 4.7 Factors for Adoption of Protein Microarrays Technology 39
39. 4.8 Top Suppliers of Protein Microarray Slides and Products 40
40. 4.9 Factors that Influence Sale Decisions 40
41. 4.10 Future Innovations in Protein Microarray Technology 40
43. 5. Current DNA Microarrays 41
44. 5.1 Key Players 41
45. 5.2 High Growth Applications 43
46. 5.2.1 Microarray-Based Commercial Genotyping Activity 43
47. 5.2.2 Location Analysis 43
48. 5.3 Future Innovations in DNA Microarray Technology 43
50. 6. Current Protein Microarrays 45
51. 6.1 Protein Profiling Microarrays-Antibody Arrays 45
52. 6.2 Protein Profiling Microarrays-Reverse Phase Microarrays 47
53. 6.3 Multiplex Sandwich Microarrays-Planar 48
54. 6.4 Multiplex Sandwich Immunoassays-Bead Based 50
55. 6.5 Microarrays for Protein Function Studies 52
56. 6.6 High Growth Applications 54
57. 6.6.1 Cytokine Arrays 54
58. 6.6.2 Whole Proteome Arrays 54
59. 6.6.3 Microarray-Based Commercial Genotyping Activity 54
60. 6.6.3.1 Microarray-Based Genotyping Applications 54
61. 6.6.3.2 Microbial Applications 55
62. 6.6.3.3 The Market for Microbial Genotyping Products 56
63. 6.6.3.4 Comparative Genomic Hybridization 56
64. 6.6.4 ChIP-on-Chip Analysis 57
66. 7. Technology 59
67. 7.1 Production of Microarrays 59
68. 7.2 2-D Versus 3-D Technology 61
69. 7.3 Substrates and Surface Chemistries 61
70. 7.4 Detection Methods 63
71. 7.5 Instruments 63
72. 7.6 Data Management and Informatics in Gene Expression 64
74. 8. Applications 65
75. 8.1 DNA Microarrays in Gene Expression 65
76. 8.2 DNA Microarrays in SNP Analysis 68
77. 8.3 DNA Microarrays in Cancer 69
78. 8.4 Protein Expression 69
79. 8.4.1 Cytokine Applications 70
80. 8.4.2 Protein Function 70
81. 8.4.3 Protein-Protein Interactions 71
82. 8.5 Target /Biomarker Discovery 71
83. 8.6 Drug Discovery and Development (Gene and Protein Microarrays) 72
84. 8.7 Clinical Diagnostics (Gene and Protein Microarrays) 72
85. 8.8 RNA Microarrays 73
86. 8.9 Oligo Microarrays 73
87. 8.10 Yeast Microarrays 74
88. 8.11 Antibody Arrays 74
90. 9. The Commercial Opportunity for Microarrays 75
91. 9.1 Market Drivers for Microarrays 75
92. 9.2 Market Restraints for Microarrays 75
93. 9.3 Key Players 76
94. 9.4 Market Size, Strategic Trends and Competitive Landscape for Protein Arrays 79
95. 9.5 Marketing and Distribution 81
96. 9.6 Protein Arrays Market Analysis 82
97. 9.7 Genes Associated with Major Diseases 83
98. 9.8 Software and Data Analysis 83
99. 9.8.1 Supplier of DNA Microarray Analysis Software 84
100. 9.8.2 Satisfaction with Software Features 84
101. 9.8.3 Satisfaction with Software 84
102. 9.8.4 Supplier Factors in Software Purchase Decision 84
103. 9.8.5 Suppliers' Role in Improving Data Sharing for DNA Microarrays 84
105. 10. Legal Aspects of Commercialization of Protein Arrays 85
107. 11. Company Profiles 87
109. Appendix 1: Microarray Milestones 124
112. LIST OF FIGURES
114. Figure 5.1: Company Market Shares 41
115. Figure 8.1: Overall Market Size by Application, 2005 66
116. Figure 8.2: Source of Variation in Microarray Data 73
119. LIST OF TABLES
121. Table 3.1: Source of DNA Microarrays in Research Use 17
122. Table 3.2: Microarray Market Drivers 17
123. Table 3.3: Microarray Market Barriers 18
124. Table 3.4: Unit Pricing of DNA Microarrays, 2000-2010 18
125. Table 3.5: Steps in the Design and Implementation of a DNA Microarray Experiment 20
126. Table 3.6: The Main Features of Some Hybridization Microarray Formats Currently Available 21
127. Table 3.7: Microarray Applications 24
128. Table 3.8: List of DNA Array Manufacturers 26
129. Table 4.1: Critical Factors for Microarray Content 33
130. Table 4.2: Top Three Suppliers of Treated Protein Microarray Surfaces for Self-Printing 40
131. Table 4.3: Top Suppliers of Commercially Available Protein Microarrays 40
132. Table 4.4: Top Suppliers of Protein Microarray Readers 40
133. Table 5.1: Affymetrix Sales of Probe Arrays, 2000-2005 42
134. Table 5.2: Affymetrix Total Product Sales, 1999-2005 42
135. Table 5.3: Affymetrix Instrument Sales, 2000-2005 42
136. Table 6.1: Microarray Genetic Testing 54
137. Table 6.2: ChIP-on-Chip Microarray Market Size Projections, 2005-2011 57
138. Table 8.1: Applications of Biochips by Class 65
139. Table 8.2: Diagnostics Microarray Market Size Projections, 2005-2011 66
140. Table 8.3: HTS Microarray Market Size Projections, 2005-2011 66
141. Table 8.4: Pharmacogenomics Microarray Market Size Projections, 2005-2011 67
142. Table 8.5: Toxicology Screening Microarray Market Size Projections, 2005-2011 67
143. Table 8.6: Expression Profiling Microarray Market Size Projections, 2005-2011 67
144. Table 9.1: Market Share of Microarray Products, 2004 76
145. Table 9.2: Affymetrix Product Sales 77
146. Table 9.3: Agilent's Net Revenue by Business Segment, 2002, 2003 and 2004 77
147. Table 9.4: Leading Microarray Companies 78
148. Table 9.5: Worldwide Microarray Market Size, 2004-2011 79
149. Table 9.6: Microarray Market Share by Technology Type 79
150. Table 9.7: DNA Microarray U.S. Market Size, 2005-2011 80
151. Table 9.8: DNA Microarray Worldwide Market Size, 2002-2011 80
152. Table 9.9: Biochip Market by Usage, 2003 and 2007 80